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Keywords:

  • hypervalent compounds;
  • iodine;
  • natural products;
  • oxidation;
  • Prins–pinacol reaction;
  • umpolung
Thumbnail image of graphical abstract

Center stage: An oxidative Prins–pinacol tandem process mediated by a hypervalent iodine reagent has been accomplished. The strategy allows rapid access to highly functionalized spirocyclic cores (see scheme) present in many natural products. A first application to the formal synthesis of (−)-platensimycin has been achieved.