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Keywords:

  • aromatic compounds;
  • asymmetric synthesis;
  • metathesis;
  • ring closure;
  • synthesis design

Abstract

Tandem ring-closing enyne metathesis (RCEM)/ring-closing olefin metathesis (RCM) of tetraenynes with Grubbs second-generation catalyst, followed by elimination, was found to be a new and efficient synthetic approach to biaryl compounds. A preliminary asymmetric version of this approach, which used homochiral Ru–alkylidene catalysts, is also presented.