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Synthesis of Biaryl Compounds Using Tandem Ruthenium-Catalyzed Ring-Closing Metathesis

Authors

  • Prof. Dr. Kazuhiro Yoshida,

    Corresponding author
    1. Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522 (Japan), Fax: (+81) 43-290-2789
    • Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522 (Japan), Fax: (+81) 43-290-2789
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  • Hiroaki Shida,

    1. Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522 (Japan), Fax: (+81) 43-290-2789
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  • Dr. Hidetoshi Takahashi,

    1. Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522 (Japan), Fax: (+81) 43-290-2789
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  • Prof. Dr. Akira Yanagisawa

    Corresponding author
    1. Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522 (Japan), Fax: (+81) 43-290-2789
    • Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522 (Japan), Fax: (+81) 43-290-2789
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Abstract

Tandem ring-closing enyne metathesis (RCEM)/ring-closing olefin metathesis (RCM) of tetraenynes with Grubbs second-generation catalyst, followed by elimination, was found to be a new and efficient synthetic approach to biaryl compounds. A preliminary asymmetric version of this approach, which used homochiral Ru–alkylidene catalysts, is also presented.

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