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Keywords:

  • asymmetric catalysis;
  • coumarins;
  • Michael addition;
  • organocatalysis;
  • thioureas
Thumbnail image of graphical abstract

Efficient excess: An efficient and facile enantioselective Michael addition reaction through hydrogen-bonding catalysis for the synthesis of coumarin complexes has been developed (see scheme). A simple bifunctional amine–thiourea small molecule has been discovered to catalyze this process with high yields and high to excellent enantiomeric excesses.