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Enantioselective Synthesis of Coumarins Catalyzed by a Bifunctional Amine–Thiourea Catalyst

Authors

  • Dr. Yaojun Gao,

    1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Fax: (+65) 6516-1691
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  • Qiao Ren,

    1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Fax: (+65) 6516-1691
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  • Lei Wang,

    1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Fax: (+65) 6516-1691
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  • Prof. Dr. Jian Wang

    Corresponding author
    1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Fax: (+65) 6516-1691
    • Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Fax: (+65) 6516-1691

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Abstract

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Efficient excess: An efficient and facile enantioselective Michael addition reaction through hydrogen-bonding catalysis for the synthesis of coumarin complexes has been developed (see scheme). A simple bifunctional amine–thiourea small molecule has been discovered to catalyze this process with high yields and high to excellent enantiomeric excesses.

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