SEARCH

SEARCH BY CITATION

Keywords:

  • alternarlactam;
  • antifungal agents;
  • antitumor agents;
  • total synthesis

Abstract

(−)-Alternarlactam [(−)-1], a new promising cytotoxin against two human cancer cell lines, was isolated from an endophyte culture and synthesized (along with (+)-1) from readily available starting materials. The absolute configuration, chirality–activity relevance and self-aggregation of (−)-1 were assigned by a combination of synthetic, spectroscopic and computational approaches. The full characterization of the new fungal cytotoxin may provide valuable information in the discovery of new antitumor agents.