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Well-Defined Air-Stable Palladium HASPO Complexes for Efficient Kumada–Corriu Cross-Couplings of (Hetero)Aryl or Alkenyl Tosylates

Authors

  • Prof. Dr. Lutz Ackermann,

    Corresponding author
    1. Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077, Göttingen (Germany), Fax: (+49) 551-39-6777
    • Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077, Göttingen (Germany), Fax: (+49) 551-39-6777
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  • Dr. Anant R. Kapdi,

    1. Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077, Göttingen (Germany), Fax: (+49) 551-39-6777
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  • Dipl.-Chem. Sabine Fenner,

    1. Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077, Göttingen (Germany), Fax: (+49) 551-39-6777
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  • Dipl.-Chem. Christoph Kornhaaß,

    1. Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077, Göttingen (Germany), Fax: (+49) 551-39-6777
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  • Dr. Carola Schulzke

    1. School of Chemistry, Trinity College Dublin, College Green, Dublin 2 (Ireland)
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Abstract

Palladium complexes of representative heteroatom-substituted secondary phosphine oxide (HASPO) preligands were synthesized and fully characterized, including X-ray crystal structure analysis. Importantly, these well-defined complexes served as highly efficient catalysts for Kumada–Corriu cross-coupling reactions of aryl, alkenyl, and even heteroaryl tosylates. Particularly, an air-stable catalyst derived from inexpensive PinP(O)H displayed a remarkably high catalytic efficacy, which resulted in cross-couplings at low catalyst loadings under exceedingly mild reaction conditions with ample scope.

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