Get access
Advertisement

Dendritic Ruthenium(II)-Based Dyes Tuneable for Diagnostic or Therapeutic Applications

Authors

  • Albert Ruggi,

    1. Supramolecular Chemistry and Technology, MESA+ Institute for Nanotechnology, University of Twente, PO Box 217, 7500 AE, Enschede (The Netherlands), Fax: (+31) 534894645
    Search for more papers by this author
  • Dr. Chantal Beekman,

    1. Division of Diagnostic Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam (The Netherlands)
    Search for more papers by this author
  • Dr. Dorothee Wasserberg,

    1. Nanobiophysics, MESA+ Institute for Nanotechnology, University of Twente, PO Box 217, 7500 AE, Enschede (The Netherlands)
    Search for more papers by this author
  • Prof. Dr. Vinod Subramaniam,

    1. Nanobiophysics, MESA+ Institute for Nanotechnology, University of Twente, PO Box 217, 7500 AE, Enschede (The Netherlands)
    Search for more papers by this author
  • Prof. Dr. David N. Reinhoudt,

    1. Supramolecular Chemistry and Technology, MESA+ Institute for Nanotechnology, University of Twente, PO Box 217, 7500 AE, Enschede (The Netherlands), Fax: (+31) 534894645
    Search for more papers by this author
  • Dr. Fijs W. B. van Leeuwen,

    1. Division of Diagnostic Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam (The Netherlands)
    Search for more papers by this author
  • Dr. Aldrik H. Velders

    Corresponding author
    1. Supramolecular Chemistry and Technology, MESA+ Institute for Nanotechnology, University of Twente, PO Box 217, 7500 AE, Enschede (The Netherlands), Fax: (+31) 534894645
    • Supramolecular Chemistry and Technology, MESA+ Institute for Nanotechnology, University of Twente, PO Box 217, 7500 AE, Enschede (The Netherlands), Fax: (+31) 534894645
    Search for more papers by this author

Abstract

original image

Shining brightly: The synthesis, characterisation and photophysical behaviour of two new luminescent dendrimers based on ruthenium(II) dyes, carrying 32 positive (1) or 32 negative (2) charges, is described. The combination of stoichiometric control and the absence of self-quenching of the ruthenium dyes results in a maximum increase in the fluorescence of the dendrimer corresponding to the number of substituents, and offers a straightforward and promising approach to the realisation of very bright labels.

Get access to the full text of this article

Ancillary