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Keywords:

  • adenosine triphosphate;
  • aptamers;
  • lysozymes;
  • multiplexed detection;
  • nanoparticles
Thumbnail image of graphical abstract

Sensing large and small simultaneously: Sensitive and multiplexed analysis of lysozyme and ATP analytes is achieved through target-induced release of aptamers from the DNA duplexes on a sensing surface, followed by backfilling hybridization of the resulting single-stranded DNAs with aptamers conjugated to the electrochemically encoded nanoparticles (see graphic).