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Communication
Aptamer/Nanoparticle-Based Sensitive, Multiplexed Electronic Coding of Proteins and Small Biomolecules through a Backfilling Strategy
Article first published online: 24 NOV 2010
DOI: 10.1002/chem.201002585
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Qian, X., Xiang, Y., Zhang, H., Chen, Y., Chai, Y. and Yuan, R. (2010), Aptamer/Nanoparticle-Based Sensitive, Multiplexed Electronic Coding of Proteins and Small Biomolecules through a Backfilling Strategy. Chem. Eur. J., 16: 14261–14265. doi: 10.1002/chem.201002585
Publication History
- Issue published online: 5 JAN 2011
- Article first published online: 24 NOV 2010
- Manuscript Received: 6 SEP 2010
Funded by
- National Natural Science Foundation of China. Grant Numbers: 20905062, 20675064
- Natural Science Foundation Project of Chongqing City. Grant Number: CSTC-2009BB5003
- State Key Laboratory of Electroanalytical Chemistry. Grant Number: SKLEAC2010009
- China Postdoctoral Science Foundation. Grant Numbers: 20090460715, 201003305
- Fundamental Research Funds for the Central Universities. Grant Number: XDJK2009B013
- Southwest University. Grant Number: SWUB2008078
- Abstract
- Article
- References
- Cited By
Keywords:
- adenosine triphosphate;
- aptamers;
- lysozymes;
- multiplexed detection;
- nanoparticles
Sensing large and small simultaneously: Sensitive and multiplexed analysis of lysozyme and ATP analytes is achieved through target-induced release of aptamers from the DNA duplexes on a sensing surface, followed by backfilling hybridization of the resulting single-stranded DNAs with aptamers conjugated to the electrochemically encoded nanoparticles (see graphic).