Communication

Rapid Carbon-11 Radiolabelling for PET Using Microfluidics

  1. Dr. Philip W. Miller1,2,*,
  2. Dr. Hélène Audrain2,
  3. Dr. Dirk Bender2,
  4. Prof. Andrew J. deMello1,
  5. Prof. Antony D. Gee1,3,
  6. Prof. Nicholas J. Long1,
  7. Dr. Ramon Vilar1

Article first published online: 3 DEC 2010

DOI: 10.1002/chem.201002644

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 17, Issue 2, pages 460–463, January 10, 2011

Additional Information

How to Cite

Miller, P. W., Audrain, H., Bender, D., deMello, A. J., Gee, A. D., Long, N. J. and Vilar, R. (2011), Rapid Carbon-11 Radiolabelling for PET Using Microfluidics. Chem. Eur. J., 17: 460–463. doi: 10.1002/chem.201002644

Author Information

  1. 1

    Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ (UK), Fax: (+44) 20-7594-5804

  2. 2

    PET-Centre, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C (Denmark)

  3. 3

    Division of Imaging Sciences, King's College London, St Thomas' Hospital, London SE1 7EH (UK)

*Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ (UK), Fax: (+44) 20-7594-5804

Publication History

  1. Issue published online: 5 JAN 2011
  2. Article first published online: 3 DEC 2010
  3. Manuscript Received: 14 SEP 2010

Funded by

  • EPSRC. Grant Number: EP/E039278/1

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Keywords:

  • carbon;
  • microfluidic reactors;
  • positron emission tomography;
  • radiochemistry;
  • radiopharmaceuticals
Thumbnail image of graphical abstract

Labels all around: A gas–liquid microfluidic reactor is used for the first time to efficiently perform [11C]carbon monoxide carbonylation reactions for the preparation of 11C-radiolabelled amide molecules within a short timeframe (<15 min; see scheme).

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