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Rapid Carbon-11 Radiolabelling for PET Using Microfluidics

Authors

  • Dr. Philip W. Miller,

    Corresponding author
    1. Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ (UK), Fax: (+44) 20-7594-5804
    2. PET-Centre, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C (Denmark)
    • Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ (UK), Fax: (+44) 20-7594-5804
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  • Dr. Hélène Audrain,

    1. PET-Centre, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C (Denmark)
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  • Dr. Dirk Bender,

    1. PET-Centre, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C (Denmark)
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  • Prof. Andrew J. deMello,

    1. Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ (UK), Fax: (+44) 20-7594-5804
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  • Prof. Antony D. Gee,

    1. Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ (UK), Fax: (+44) 20-7594-5804
    2. Division of Imaging Sciences, King's College London, St Thomas' Hospital, London SE1 7EH (UK)
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  • Prof. Nicholas J. Long,

    1. Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ (UK), Fax: (+44) 20-7594-5804
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  • Dr. Ramon Vilar

    1. Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ (UK), Fax: (+44) 20-7594-5804
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Abstract

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Labels all around: A gas–liquid microfluidic reactor is used for the first time to efficiently perform [11C]carbon monoxide carbonylation reactions for the preparation of 11C-radiolabelled amide molecules within a short timeframe (<15 min; see scheme).

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