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pH-Triggered Self-Assembly of Zwitterionic Polyglycerol Dendrons into Discrete and Highly Stable Supramolecular Dendrimers in Water

Authors

  • Dipl.-Chem. Michael Merschky,

    1. Lehrstuhl für Organische Chemie 2, Fakultät für Chemie, Universität Duisburg-Essen, Universitätsstrasse 7, 45141 Essen (Germany), Fax: (+49) 201-183-4259
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  • Dr. Monika Wyszogrodzka,

    1. Organische Chemie, Technische Universität Dortmund, Otto-Hahn-Strasse 6, 44225 Dortmund (Germany)
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  • Prof. Dr. Rainer Haag,

    1. Institut für Chemie und Biochemie - Organische Chemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin (Germany)
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  • Prof. Dr. Carsten Schmuck

    Corresponding author
    1. Lehrstuhl für Organische Chemie 2, Fakultät für Chemie, Universität Duisburg-Essen, Universitätsstrasse 7, 45141 Essen (Germany), Fax: (+49) 201-183-4259
    • Lehrstuhl für Organische Chemie 2, Fakultät für Chemie, Universität Duisburg-Essen, Universitätsstrasse 7, 45141 Essen (Germany), Fax: (+49) 201-183-4259
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Abstract

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pH-dependent dimerization: Zwitterionic polyglycerol dendrons self-assemble into discrete and well-defined dimers in water as shown by dynamic light scattering (DLS), gel permeability chromatography (GPC), and DOSY NMR spectroscopy. However, self-assembly occurs only at neutral pH as either protonation or deprotonation destroys the self-complementary zwitterionic binding motif in the core of the dendrimer. Hence, structure formation can be triggered back and forth by changing the pH of the solution.

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