pH-dependent dimerization: Zwitterionic polyglycerol dendrons self-assemble into discrete and well-defined dimers in water as shown by dynamic light scattering (DLS), gel permeability chromatography (GPC), and DOSY NMR spectroscopy. However, self-assembly occurs only at neutral pH as either protonation or deprotonation destroys the self-complementary zwitterionic binding motif in the core of the dendrimer. Hence, structure formation can be triggered back and forth by changing the pH of the solution.
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