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Microwave-Promoted Selective Mono-N-Alkylation of Anilines with Tertiary Amines by Heterogeneous Catalysis

Authors

  • Dr. M. Caterina Lubinu,

    1. Dipartimento di Chimica, Università degli Studi di Sassari via Vienna 2, 07100 Sassari (Italy), Fax: (+39) 079212069
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  • Dr. Lidia De Luca,

    1. Dipartimento di Chimica, Università degli Studi di Sassari via Vienna 2, 07100 Sassari (Italy), Fax: (+39) 079212069
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  • Prof. Giampaolo Giacomelli,

    1. Dipartimento di Chimica, Università degli Studi di Sassari via Vienna 2, 07100 Sassari (Italy), Fax: (+39) 079212069
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  • Dr. Andrea Porcheddu

    Corresponding author
    1. Dipartimento di Chimica, Università degli Studi di Sassari via Vienna 2, 07100 Sassari (Italy), Fax: (+39) 079212069
    • Dipartimento di Chimica, Università degli Studi di Sassari via Vienna 2, 07100 Sassari (Italy), Fax: (+39) 079212069
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Abstract

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A palladium-catalyzed N-alkylation of anilines with tertiary amines that occurs under heterogeneous transfer-hydrogenation conditions has been developed (see scheme). This protocol of transamination, which uses a relatively cheap and easily recyclable heterogeneous catalyst, can be efficiently applied to different substrates and is suitable for large-scale preparations.

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