Full Paper

2′-O,4′-C-Aminomethylene-Bridged Nucleic Acid Modification with Enhancement of Nuclease Resistance Promotes Pyrimidine Motif Triplex Nucleic Acid Formation at Physiological pH

  1. Prof. Hidetaka Torigoe1,*,
  2. Dr. S. M. Abdur Rahman2,
  3. Hiroko Takuma2,
  4. Norihiro Sato1,
  5. Prof. Takeshi Imanishi2,
  6. Prof. Satoshi Obika2,
  7. Kiyomi Sasaki1

Article first published online: 24 JAN 2011

DOI: 10.1002/chem.201002745

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 17, Issue 9, pages 2742–2751, February 25, 2011

Additional Information

How to Cite

Torigoe, H., Rahman, S. M. A., Takuma, H., Sato, N., Imanishi, T., Obika, S. and Sasaki, K. (2011), 2′-O,4′-C-Aminomethylene-Bridged Nucleic Acid Modification with Enhancement of Nuclease Resistance Promotes Pyrimidine Motif Triplex Nucleic Acid Formation at Physiological pH. Chem. Eur. J., 17: 2742–2751. doi: 10.1002/chem.201002745

Author Information

  1. 1

    Departmentof Applied Chemistry, Faculty of Science, Tokyo University of Science, 1–3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601 (Japan), Fax: (+81) 3-5261-4631

  2. 2

    Graduate School of Pharmaceutical Sciences, Osaka University, 1–6 Yamadaoka, Suita, Osaka 565-0871 (Japan)

*Departmentof Applied Chemistry, Faculty of Science, Tokyo University of Science, 1–3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601 (Japan), Fax: (+81) 3-5261-4631

Publication History

  1. Issue published online: 17 FEB 2011
  2. Article first published online: 24 JAN 2011
  3. Manuscript Revised: 28 NOV 2010
  4. Manuscript Received: 24 SEP 2010

Funded by

  • Grant-in-Aid for Scientific Research. Grant Number: 22113519
  • Grant-in-Aid for Exploratory Research. Grant Number: 20655038
  • Grant-in-Aid for Scientific Research. Grant Number: 21350094
  • Grant-in-Aid for JSPS Fellows. Grant Number: 22-10383
  • Ministry of Education, Science, Sports, and Culture of Japan
  • National Institute of Biomedical Innovation (NIBIO)

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View Full Article with Supporting Information (HTML) Get PDF (381K)