Palladium-Catalyzed Three-Component Reaction of 2,3-Allenyl Amines, Isocyanates, and Organic Halides: A Diversified Assembly of Imidazolidinones

Authors

  • Wei Shu,

    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032 (P. R. China), Fax: (+86) 21-62609305
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  • Qiong Yu,

    1. Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062 (P. R. China)
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  • Prof. Dr. Guochen Jia,

    Corresponding author
    1. Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong (P.R. China)
    • Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong (P.R. China)
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  • Prof. Dr. Shengming Ma

    Corresponding author
    1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032 (P. R. China), Fax: (+86) 21-62609305
    2. Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062 (P. R. China)
    • State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032 (P. R. China), Fax: (+86) 21-62609305
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Abstract

original image

A three-component reaction of 2,3-allenyl amines with isocyanates and organic halides has been developed. Two carbon–nitrogen bonds as well as a carbon–carbon bond were sequentially formed to construct imidazolidinone derivatives in good to excellent yields (see scheme).

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