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Cross-Coupling of Aryl/Alkenyl Ethers with Aryl Grignard Reagents through Nickel-Catalyzed C[BOND]O Activation

Authors

  • Lan-Gui Xie,

    1. CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P.R. China), Fax: (+86) 551-3601592
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  • Prof. Dr. Zhong-Xia Wang

    Corresponding author
    1. CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P.R. China), Fax: (+86) 551-3601592
    • CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P.R. China), Fax: (+86) 551-3601592
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Abstract

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The formation of a C[BOND]C bond has been achieved through the cleavage of the sp2 C[BOND]O bond of aryl/alkenyl ethers catalyzed by a nickel complex, and by using Grignard reagents as nucleophiles (see scheme). This method displays a broad substrate scope and leads to good to excellent yields of the aryl–aryl or alkenyl–aryl cross-coupling products.

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