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Cover Picture
Cover Picture: Stable Anticancer Gold(III)–Porphyrin Complexes: Effects of Porphyrin Structure (Chem. Eur. J. 10/2010)
Article first published online: 1 MAR 2010
DOI: 10.1002/chem.201090039
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Sun, R.-Y., Li, C.-L., Ma, D.-L., Yan, J., Lok, C.-N., Leung, C.-H., Zhu, N. and Che, C.-M. (2010), Cover Picture: Stable Anticancer Gold(III)–Porphyrin Complexes: Effects of Porphyrin Structure (Chem. Eur. J. 10/2010). Chem. Eur. J., 16: 2951. doi: 10.1002/chem.201090039
Publication History
- Issue published online: 1 MAR 2010
- Article first published online: 1 MAR 2010
Keywords:
- antitumor agents;
- bioinorganic chemistry;
- DNA;
- G quadruplexes;
- porphyrinoids
Stable gold(III)–porphyrin complexes display promising in vitro cyctotoxic and anti-angiogenic activity as described in the Full Paper by C.-M. Che et al. on page 3097 ff. Strongly chelating phorphyrinato ligands were used to stabilize the gold(III) ion and the structure–bioactivity relationship of a range of compounds was investigated. The biological properties and ease of structural modification of the gold(III)–porphyrins suggest that this family of lipophilic cations would be a suitable choice for the development of future therapeutic applications.