Palladium-Catalyzed Direct Arylations of Azoles with Aryl Silicon and Tin Reagents

Authors

  • Wei Han,

    1. Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5–13, 81377 München (Germany), Fax: (+49) 89-2180-9977715
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  • Dr. Peter Mayer,

    1. Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5–13, 81377 München (Germany), Fax: (+49) 89-2180-9977715
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  • Dr. Armin R. Ofial

    Corresponding author
    1. Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5–13, 81377 München (Germany), Fax: (+49) 89-2180-9977715
    • Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5–13, 81377 München (Germany), Fax: (+49) 89-2180-9977715
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Abstract

original image

Regioselective arylations of imidazoles, oxazoles, and thiazoles were achieved by palladium-catalyzed cross-coupling with trialkoxy(aryl)silanes or allyltriphenylstannane (see scheme). Addition of ligands or exclusion of moisture was not necessary to obtain C2-substituted azoles in high yields.

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