Nickel-Catalyzed Intramolecular Nucleophilic Addition of Aryl or Vinyl Chlorides to α-Ketoamides Through C[BOND]Cl Bond Activation

Authors

  • Jin-Xiu Hu,

    1. The State Key Laboratory Breeding Base of Green, Chemistry–Synthesis Technology, Zhejiang University of Technology, Chaowang Road 18, Hangzhou, 310014 (P.R. China), Fax: (+86) 571-88320544
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  • Hao Wu,

    1. The State Key Laboratory Breeding Base of Green, Chemistry–Synthesis Technology, Zhejiang University of Technology, Chaowang Road 18, Hangzhou, 310014 (P.R. China), Fax: (+86) 571-88320544
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  • Prof. Dr. Chuan-Ying Li,

    1. Department of Chemistry, Zhejiang Sci-Tech University, 5 Second Avenue, Xiasha Higher Education Zone, Hangzhou, 310018 (P.R. China)
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  • Wei-Jian Sheng,

    1. The State Key Laboratory Breeding Base of Green, Chemistry–Synthesis Technology, Zhejiang University of Technology, Chaowang Road 18, Hangzhou, 310014 (P.R. China), Fax: (+86) 571-88320544
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  • Prof. Dr. Yi-Xia Jia,

    Corresponding author
    1. The State Key Laboratory Breeding Base of Green, Chemistry–Synthesis Technology, Zhejiang University of Technology, Chaowang Road 18, Hangzhou, 310014 (P.R. China), Fax: (+86) 571-88320544
    • The State Key Laboratory Breeding Base of Green, Chemistry–Synthesis Technology, Zhejiang University of Technology, Chaowang Road 18, Hangzhou, 310014 (P.R. China), Fax: (+86) 571-88320544
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  • Prof. Dr. Jian-Rong Gao

    Corresponding author
    1. The State Key Laboratory Breeding Base of Green, Chemistry–Synthesis Technology, Zhejiang University of Technology, Chaowang Road 18, Hangzhou, 310014 (P.R. China), Fax: (+86) 571-88320544
    • The State Key Laboratory Breeding Base of Green, Chemistry–Synthesis Technology, Zhejiang University of Technology, Chaowang Road 18, Hangzhou, 310014 (P.R. China), Fax: (+86) 571-88320544
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Abstract

original image

Nickeleophilic addition! The first example of a nickel-catalyzed direct intramolecular nucleophilic addition of aryl or vinyl chlorides to α-ketoamides through C[BOND]Cl bond activation is reported, which takes place under mild reaction conditions (see scheme).

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