A Metathesis Approach to Volatile Olefins: Synthesis of 18O-Allyl Alcohol

Authors

  • Prof. Dr. Guy C. Lloyd-Jones,

    Corresponding author
    1. School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS (UK), Fax: (+44) 117-9251295
    • School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS (UK), Fax: (+44) 117-9251295
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  • Dr. Sophie Purser

    1. School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS (UK), Fax: (+44) 117-9251295
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Abstract

original image

A neat reaction: A ring-closing metathesis (RCM) strategy is presented in which the two termini of a light, and thus volatile, isotopically labelled olefin are held separate by way of a higher molecular weight diene component, allowing synthetic manipulations to be conducted without difficulty. Using simple laboratory apparatus, a solvent-free catalytic RCM process can be achieved that avoids side reactions and allows isolation of the alkene in high purity.

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