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Palladium-Catalyzed Borylation of Aryl Mesylates and Tosylates and Their Applications in One-Pot Sequential Suzuki–Miyaura Biaryl Synthesis

Authors

  • Wing Kin Chow,

    1. State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom Kowloon (Hong Kong), Fax: (+852) 2364-9932
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  • Dr. Chau Ming So,

    1. State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom Kowloon (Hong Kong), Fax: (+852) 2364-9932
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  • Prof. Dr. Chak Po Lau,

    1. State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom Kowloon (Hong Kong), Fax: (+852) 2364-9932
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  • Prof. Dr. Fuk Yee Kwong

    Corresponding author
    1. State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom Kowloon (Hong Kong), Fax: (+852) 2364-9932
    • State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom Kowloon (Hong Kong), Fax: (+852) 2364-9932
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Abstract

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Top of the one-pots! The first palladium-catalyzed borylation of aryl tosylates and mesylates is described. The reaction conditions are mild and provide excellent functional-group compatibility (e.g., R=CN, CHO, COOMe, C(O)R, NH2, or NH-indole; see scheme). Pd/MeO-CM-phos allows one-pot sequential reactions in the preparation of unsymmetrical biaryls.

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