Ruthenium Catalysts Containing Rigid Chiral Diamines and Achiral Diphosphanes for Highly Enantioselective Hydrogenation of Aromatic Ketones

Authors

  • Qiming Zhu,

    1. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000 (P.R. China), Fax: (+86) 931-496-8129
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  • Dengjian Shi,

    1. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000 (P.R. China), Fax: (+86) 931-496-8129
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  • Prof. Dr. Chungu Xia,

    1. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000 (P.R. China), Fax: (+86) 931-496-8129
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  • Prof. Dr. Hanmin Huang

    Corresponding author
    1. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000 (P.R. China), Fax: (+86) 931-496-8129
    • State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000 (P.R. China), Fax: (+86) 931-496-8129
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Abstract

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One chiral element is enough: A new ruthenium catalyst containing a rigid chiral diamine (BIDN) and a commercially available inexpensive achiral phosphane (DPPF) is highly efficient for the enantioselective hydrogenation of ketones (see scheme). High reactivity (S/C up to 100 000) and excellent enantioselectivities (up to 99 % ee) were obtained.

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