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Direct Enantioselective Amination of α-Ketoesters Catalyzed by an Axially Chiral Guanidine Base

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Errata

This article is corrected by:

  1. Errata: Corrigendum: Direct Enantioselective Amination of α-Ketoesters Catalyzed by an Axially Chiral Guanidine Base Volume 17, Issue 36, 9858, Article first published online: 22 August 2011

Abstract

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β-functional! Direct enantioselective amination of α-ketoesters with azodicarboxylates was demonstrated using an axially chiral guanidine base catalyst, which enabled efficient access to enantioenriched multifunctionalized ketoesters with an aliphatic substituent at the β-position. Subsequent nucleophilic addition to the β-hydrazinyl-α-ketoester at the reactive ketone yields the corresponding β-hydrazinyl-α-hydroxy esters in high syn diastereo- and enantioselectivities (see scheme).

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