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Keywords:

  • aldehydes;
  • ketones;
  • organocatalysts;
  • solvent-free;
  • trimethylsilylcyanation
Thumbnail image of graphical abstract

Mild & green: The commercially and readily available PNPCl behaves as a very effective catalyst for the synthesis of various trimethylsilyl cyanohydrins from a wide range of aliphatic, cyclic, α,β-unsaturated and aromatic ketones. The method proceeds at room temperature in solvent-free conditions, in the presence of very small amounts of catalyst (see scheme).