Selective Recognition of Co-assembled Thrombin Aptamer and Docetaxel on Mesoporous Silica Nanoparticles against Tumor Cell Proliferation

Authors

  • Liang Gao,

    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Colloid and Interface Science, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Zhong Guan Cun, Beijing, 100190 (P.R. China), Fax: (+86) 10-8261-4087
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  • Dr. Yue Cui,

    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Colloid and Interface Science, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Zhong Guan Cun, Beijing, 100190 (P.R. China), Fax: (+86) 10-8261-4087
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  • Prof. Dr. Qiang He,

    1. Micro/Nano Technology Research Centre, Harbin Institute of Technology, Harbin, 150080 (P.R. China)
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  • Dr. Yang Yang,

    1. National Center for Nanoscicence and Technology, No. 11, Bei Yi Tiao, Zhong Guan Cun, Beijing, 100190 (P.R. China)
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  • Dr. Jinbo Fei,

    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Colloid and Interface Science, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Zhong Guan Cun, Beijing, 100190 (P.R. China), Fax: (+86) 10-8261-4087
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  • Prof. Dr. Junbai Li

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Colloid and Interface Science, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Zhong Guan Cun, Beijing, 100190 (P.R. China), Fax: (+86) 10-8261-4087
    • Beijing National Laboratory for Molecular Sciences, Key Laboratory of Colloid and Interface Science, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Zhong Guan Cun, Beijing, 100190 (P.R. China), Fax: (+86) 10-8261-4087
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Abstract

original image

Delivery plan: Thrombin binding aptamer tethered to lipid-coated mesoporous silica nanoparticles (TBA A15–lipid–MSN, above arrow) were rationally designed to deliver docetaxel for combined tumor cell suppression. The dual function of the bioconjugates in the extracellular matrix and cytoplasm of HeLa cells was demonstrated. This hybrid system could be extended for combined anticancer treatment when PAR-1 is over-expressed.

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