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Keywords:

  • cyclization;
  • cyclohexadienone;
  • domino reactions;
  • multicomponent reactions;
  • skipped diynes
Thumbnail image of graphical abstract

Diverting is the game! A new domino manifold has been implemented for the synthesis of cyclohexadienone-based scaffolds from tertiary skipped diynes and secondary amines. The manifold takes advantage of a new O-enolate-driven reactivity pattern discovered for these diynes. The scaffolds are conveniently transformed into the corresponding multivalent salicylate derivatives (see scheme).