Communication

BDPA: An Efficient Polarizing Agent for Fast Dissolution Dynamic Nuclear Polarization NMR Spectroscopy†

  1. Dr. Lloyd Lumata1,
  2. Dr. S. James Ratnakar1,
  3. Dr. Ashish Jindal1,
  4. Prof. Dr. Matthew Merritt1,
  5. Prof. Dr. Arnaud Comment2,
  6. Prof. Dr. Craig Malloy1,
  7. Prof. Dr. A. Dean Sherry1,3,
  8. Prof. Dr. Zoltan Kovacs1,*

Article first published online: 25 AUG 2011

DOI: 10.1002/chem.201102037

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 17, Issue 39, pages 10825–10827, September 19, 2011

Additional Information

How to Cite

Lumata, L., Ratnakar, S. J., Jindal, A., Merritt, M., Comment, A., Malloy, C., Sherry, A. D. and Kovacs, Z. (2011), BDPA: An Efficient Polarizing Agent for Fast Dissolution Dynamic Nuclear Polarization NMR Spectroscopy. Chem. Eur. J., 17: 10825–10827. doi: 10.1002/chem.201102037

Author Information

  1. 1

    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8568 (USA), Fax: (+1) 214-645-2744

  2. 2

    Institute of Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne (Switzerland)

  3. 3

    Department of Chemistry, University of Texas at Dallas, Richardson, Texas 75080 (USA)

*Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8568 (USA), Fax: (+1) 214-645-2744

  1. †

    BDPA=1,3-bisdiphenylene-2-phenylallyl

Publication History

  1. Issue published online: 14 SEP 2011
  2. Article first published online: 25 AUG 2011
  3. Manuscript Received: 1 JUL 2011

Funded by

  • NIH. Grant Numbers: 1R21EB009147, RR02584, Swiss NSF, 200020-124901

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Keywords:

  • dynamic nuclear polarization;
  • hyperpolarization;
  • NMR spectroscopy;
  • radicals;
  • relaxation
Thumbnail image of graphical abstract

Teaching an old free radical new tricks: The stable free radical 1,3-bisdiphenylene-2-phenylallyl (BDPA) is an efficient polarizing agent in the dissolution dynamic nuclear polarization (DNP) of a variety of hydrophilic and hydrophobic compounds, such as tetramethylallene or [15N]choline (see figure). In addition, BDPA can be easily removed from the hyperpolarized solution by a simple mechanical filtration, when water is used for dissolution.

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