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Keywords:

  • aerobic oxidation;
  • biomimetics;
  • homogeneous catalysis;
  • lactonization;
  • ruthenium
Thumbnail image of graphical abstract

Coming up for air: Highly efficient aerobic lactonization can be carried out by a biomimetic oxidation system based on coupled redox catalysts (ruthenium catalyst and electron transfer mediators). This system leads to a low-energy electron transfer from diol to molecular oxygen. Various diols were aerobically oxidized to the corresponding five- to nine-membered lactones in good to high yields under mild reaction conditions (see scheme).