An Investigation into the Formation of Annular Aggregates of Human Islet Amyloid Polypeptide on Tantalum Oxide Surfaces

Authors

  • Meisha Chen,

    1. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China), Fax: (+86) 10-62781695
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  • Shuai Zhang,

    1. Interdisciplinary Nanoscience Center (iNANO) and Department of Physics and Astronomy, Aarhus University, 8000 Aarhus C (Denmark), Fax: (+45) 8942-3690
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  • Qian Liu,

    1. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China), Fax: (+86) 10-62781695
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  • Peng Liu,

    1. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China), Fax: (+86) 10-62781695
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  • Dr. Katerina Busuttil,

    1. Interdisciplinary Nanoscience Center (iNANO) and Department of Physics and Astronomy, Aarhus University, 8000 Aarhus C (Denmark), Fax: (+45) 8942-3690
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  • Prof. Chen Wang,

    1. National Center for Nanoscience and Technology, Beijing 100190 (P.R. China)
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  • Prof. Flemming Besenbacher,

    Corresponding author
    1. Interdisciplinary Nanoscience Center (iNANO) and Department of Physics and Astronomy, Aarhus University, 8000 Aarhus C (Denmark), Fax: (+45) 8942-3690
    • Interdisciplinary Nanoscience Center (iNANO) and Department of Physics and Astronomy, Aarhus University, 8000 Aarhus C (Denmark), Fax: (+45) 8942-3690
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  • Prof. Dr. Yan-Mei Li,

    Corresponding author
    1. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China), Fax: (+86) 10-62781695
    • Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China), Fax: (+86) 10-62781695
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  • Dr. Mingdong Dong

    Corresponding author
    1. Interdisciplinary Nanoscience Center (iNANO) and Department of Physics and Astronomy, Aarhus University, 8000 Aarhus C (Denmark), Fax: (+45) 8942-3690
    • Interdisciplinary Nanoscience Center (iNANO) and Department of Physics and Astronomy, Aarhus University, 8000 Aarhus C (Denmark), Fax: (+45) 8942-3690
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Abstract

original image

Annular aggregation: Atomic force microscopy and the recently developed microsecond force spectroscopy are used to identify a new annular structure of human Islet amyloid polypeptide on negatively charged tantalum oxide, a substrate that has the same surface charge as cell membranes (see figure). Finally, an accumulation model is proposed to explain how annular aggregation is initiated and developed.

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