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Controlled Synthesis of Uniform and Monodisperse Upconversion Core/Mesoporous Silica Shell Nanocomposites for Bimodal Imaging

  1. Jianan Liu1,
  2. Prof. Wenbo Bu1,*,
  3. Shengjian Zhang2,3,
  4. Feng Chen1,
  5. Huaiyong Xing1,
  6. Limin Pan1,
  7. Prof. Liangping Zhou2,3,
  8. Prof. Weijun Peng2,3,
  9. Prof. Jianlin Shi1,*

Article first published online: 17 JAN 2012

DOI: 10.1002/chem.201102599

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 18, Issue 8, pages 2335–2341, February 20, 2012

Additional Information

How to Cite

Liu, J., Bu, W., Zhang, S., Chen, F., Xing, H., Pan, L., Zhou, L., Peng, W. and Shi, J. (2012), Controlled Synthesis of Uniform and Monodisperse Upconversion Core/Mesoporous Silica Shell Nanocomposites for Bimodal Imaging. Chem. Eur. J., 18: 2335–2341. doi: 10.1002/chem.201102599

Author Information

  1. 1

    State Key Laboratory of High Performance, Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, No.1295 Ding-xi Road, Shanghai, 200050 (P.R. China), Fax: (+86) 21-5241-3122

  2. 2

    Department of Radiology, Shanghai Cancer Hospital Fudan University, Shanghai, 200032 (P.R. China)

  3. 3

    Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032 (China)

*State Key Laboratory of High Performance, Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, No.1295 Ding-xi Road, Shanghai, 200050 (P.R. China), Fax: (+86) 21-5241-3122

Publication History

  1. Issue published online: 10 FEB 2012
  2. Article first published online: 17 JAN 2012
  3. Manuscript Received: 21 AUG 2011

Funded by

  • National Natural Science Foundation of China Research. Grant Numbers: 50972154, 50823007, 51072212
  • National Basic Research Program of China. Grant Number: 2011CB707905
  • Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures. Grant Number: SKL201001

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Keywords:

  • bimodal imaging;
  • core–shell structures;
  • mesoporous materials;
  • nanoparticles;
  • silica

Abstract

Here we report the design and controlled synthesis of monodisperse and precisely size-controllable UCNP@mSiO2 nanocomposites smaller than 50 nm by directly coating a mesoporous silica shell (mSiO2) on upconversion nanocrystals NaYF4:Tm/Yb/Gd (UCNPs), which can be used as near-infrared fluorescence and magnetic resonance imaging (MRI) agents and a platform for drug delivery as well. Some key steps such as transferring hydrophobic UCNPs to the water phase by using cetyltrimethylammonium bromide (CTAB), removal of the excess amount of CTAB, and temperature-controlled ultrasonication treatment should be adopted and carefully monitored to obtain uniform upconversion core/mesoporous silica shell nanocomposites. The excellent performance of the core–shell-structured nanocomposite in near-infrared fluorescence and magnetic resonance imaging was also demonstrated.

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