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A “Clickable” Styryl Dye for Fluorescent DNA Labeling by Excitonic and Energy Transfer Interactions

Authors

  • Dipl.-Ing. Moritz M. Rubner,

    1. Karlsruhe Institute for Technology, Institute for Organic Chemistry, Fritz-Haber-Weg 6, 76131 Karlsruhe (Germany), Fax: (+49) 721-608-44825
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  • Dipl.-Chem. Carolin Holzhauser,

    1. Karlsruhe Institute for Technology, Institute for Organic Chemistry, Fritz-Haber-Weg 6, 76131 Karlsruhe (Germany), Fax: (+49) 721-608-44825
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  • Dipl.-Chem. Peggy R. Bohländer,

    1. Karlsruhe Institute for Technology, Institute for Organic Chemistry, Fritz-Haber-Weg 6, 76131 Karlsruhe (Germany), Fax: (+49) 721-608-44825
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  • Prof. Hans-Achim Wagenknecht

    Corresponding author
    1. Karlsruhe Institute for Technology, Institute for Organic Chemistry, Fritz-Haber-Weg 6, 76131 Karlsruhe (Germany), Fax: (+49) 721-608-44825
    • Karlsruhe Institute for Technology, Institute for Organic Chemistry, Fritz-Haber-Weg 6, 76131 Karlsruhe (Germany), Fax: (+49) 721-608-44825
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Abstract

original image

Turn on and turn red: The CyIQ dye as an internal DNA label can be combined with itself and thiazole red as intrastrand fluorophore pairs (see figure). Excitonic and energy transfer interactions provide interesting alternatives for fluorescence readouts, which are either fluorescence enhancement or fluorescence color change, respectively.

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