A Discrete Five-Coordinate NiIII Complex Resembling the Active Site of the Oxidized Form of Nickel Superoxide Dismutase

Authors

  • Prof. Way-Zen Lee,

    Corresponding author
    1. Department of Chemistry, National Taiwan Normal University No. 88, Sec. 4, Ting-Chow Road, Taipei 11677, R.O.C. (Taiwan), Fax: (+886) 2-29324249
    • Department of Chemistry, National Taiwan Normal University No. 88, Sec. 4, Ting-Chow Road, Taipei 11677, R.O.C. (Taiwan), Fax: (+886) 2-29324249
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  • Chien-Wei Chiang,

    1. Department of Chemistry, National Taiwan Normal University No. 88, Sec. 4, Ting-Chow Road, Taipei 11677, R.O.C. (Taiwan), Fax: (+886) 2-29324249
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  • Tsung-Han Lin,

    1. Department of Chemistry, National Taiwan Normal University No. 88, Sec. 4, Ting-Chow Road, Taipei 11677, R.O.C. (Taiwan), Fax: (+886) 2-29324249
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  • Ting-Shen Kuo

    1. Instrumentation Center, Department of Chemistry, National Taiwan Normal University, No. 88, Sec. 4, Ting-Chow Rd, Taipei 11677, R.O.C. (Taiwan)
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Abstract

original image

Nickel biomimic: A pentadentate ligand, 2,6-bis(((S)-2-(diphenylhydroxymethyl)-1-pyrrolidinyl)methyl)pyridine (H2BDPP), was deprotonated and subsequently reacted with [Ni(CH3CN)6](ClO4)2 to give Ni(BDPP) (1). A square-pyramidal NiIII complex, [Ni(BDPP)](PF6) (2), was obtained via oxidation of 1. Complex 2 can oxidize O2 into O2 and its EPR spectrum is similar to that of the oxidized form of NiSOD.

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