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Tandem Arrays of TEMPO and Nitronyl Nitroxide Radicals with Designed Arrangements on DNA

Authors

  • Hiroshi Atsumi,

    1. Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research (ISIR), Osaka University, Ibaraki 567-0047 (Japan)
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  • Dr. Kensuke Maekawa,

    1. Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research (ISIR), Osaka University, Ibaraki 567-0047 (Japan)
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  • Dr. Shigeaki Nakazawa,

    1. Departments of Chemistry and Materials Science, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka 558-8585 (Japan)
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  • Prof. Dr. Daisuke Shiomi,

    1. Departments of Chemistry and Materials Science, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka 558-8585 (Japan)
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  • Prof. Dr. Kazunobu Sato,

    1. Departments of Chemistry and Materials Science, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka 558-8585 (Japan)
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  • Prof. Dr. Masahiro Kitagawa,

    1. Graduate School of Engineering Science, Osaka University, Toyonaka 560-8531 (Japan)
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  • Prof. Dr.  Takeji Takui,

    1. Departments of Chemistry and Materials Science, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka 558-8585 (Japan)
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  • Prof. Dr. Kazuhiko Nakatani

    Corresponding author
    1. Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research (ISIR), Osaka University, Ibaraki 567-0047 (Japan)
    • Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research (ISIR), Osaka University, Ibaraki 567-0047 (Japan)
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  • TEMPO=2,2,6,6-tetramethylpiperidine N-oxide

Abstract

Herein we describe one-dimensional electron-spin arrays consisting of two different organic radicals with the designed arrangement based on the DNA sequence. Two mismatch-binding ligands carrying 2,2,6,6-tetramethylpiperidine N-oxide (TEMPO) and nitronyl nitroxide selectively bind to the predetermined sites on double stranded DNA. By using the two mismatch-binding ligands carrying the organic radicals as the glue for DNA, electron-spin assembly could be successfully synchronized with the hybridization. Periodically and tandemly arranged, two kinds of organic radical molecules at designed positions might be useful for an approach to build up scalable qubits of electron-spin-based quantum computing. The approach using DNA nanostructures as a scaffold to assembly functional small molecules can afford one of the promising ways for the future application of DNA nanostructures and nanotechnology.

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