Get access

Asymmetric Synthesis of β-Adrenergic Blockers through Multistep One-Pot Transformations Involving In Situ Chiral Organocatalyst Formation

Authors

  • Dr. Shengwei Wei,

    1. Department of Chemistry and Pharmacy, Chair of Organic Chemistry I, University of Erlangen-Nuremberg, Henkestrasse 42, 91054 Erlangen (Germany), Fax: (+49) 9131-85-26865
    Search for more papers by this author
  • Regina Messerer,

    1. Department of Chemistry and Pharmacy, Chair of Organic Chemistry I, University of Erlangen-Nuremberg, Henkestrasse 42, 91054 Erlangen (Germany), Fax: (+49) 9131-85-26865
    Search for more papers by this author
  • Prof. Dr. Svetlana B. Tsogoeva

    Corresponding author
    1. Department of Chemistry and Pharmacy, Chair of Organic Chemistry I, University of Erlangen-Nuremberg, Henkestrasse 42, 91054 Erlangen (Germany), Fax: (+49) 9131-85-26865
    • Department of Chemistry and Pharmacy, Chair of Organic Chemistry I, University of Erlangen-Nuremberg, Henkestrasse 42, 91054 Erlangen (Germany), Fax: (+49) 9131-85-26865
    Search for more papers by this author

Abstract

original image

Two birds one stone: A new atom-economical one-pot approach to enantioselective chiral drug synthesis, involving in situ multistep organocatalyst formation and the application of the reaction for multistep sequential synthesis of β-adrenergic blockers is disclosed (see scheme).

Ancillary