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Pd-Catalyzed Multiple C[BOND]H Functionalization to Construct Biologically Active Compounds from Aryl Aldoxime Ethers with Arenes

Authors

  • Dr. Vedhagiri S. Thirunavukkarasu,

    1. Department of Chemistry, National Tsing Hua University, Hsinchu, 30013 (Taiwan), Fax: (+886) 35724698
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  • Prof. Dr. Chien-Hong Cheng

    Corresponding author
    1. Department of Chemistry, National Tsing Hua University, Hsinchu, 30013 (Taiwan), Fax: (+886) 35724698
    • Department of Chemistry, National Tsing Hua University, Hsinchu, 30013 (Taiwan), Fax: (+886) 35724698
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Abstract

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Functional fluorenones: Aromatic aldoxime ethers react with unactivated arenes catalyzed by palladium complexes to give biologically active fluoren-9-ones (see scheme). Multiple C[BOND]H bond activation and an oxidative cyclization are involved in the reaction.

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