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New Ruthenium(II) Complexes Functionalized with Coumarin Derivatives: Synthesis, Energy-Transfer-Based Sensing of Esterase, Cytotoxicity, and Imaging Studies

Authors

  • Dr. Mei-Jin Li,

    1. Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR (P.R. China)
    2. Key Laboratory of Analysis and Detection Technology for Food Safety (Ministry of Education and Fujian Province), Department of Chemistry, Fuzhou University, Fuzhou 350108 (P.R. China)
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  • Dr. Keith Man-Chung Wong,

    1. Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR (P.R. China)
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  • Dr. Changqing Yi,

    1. School of Engineering, Sun Yat-Sen University, Guangzhou 510275 (P.R. China)
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  • Prof. Vivian Wing-Wah Yam

    Corresponding author
    1. Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR (P.R. China)
    • Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR (P.R. China)
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Abstract

Two new bichromophoric ruthenium(II) complexes, [Ru(bpy)2(bpy-CM)](PF6)2 and [Ru(bpy)2(bpy-CM343)](PF6)2 (bpy=2,2′-bipyridine, CM=coumarin) with appended coumarin ligands have been designed and synthesized. The energy-transfer-based sensing of esterase by the complexes has been studied by using UV/Vis and luminescence spectroscopic methods. The cytotoxicity and the cellular uptake of one of the complexes have also been investigated.

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