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Supramolecular Dendrimers: Convenient Synthesis by Programmed Self-Assembly and Tunable Thermoresponsivity

  1. Dr. Partha S. Ghosh1,
  2. Prof. Dr. Andrew D. Hamilton1,2,*

Article first published online: 20 JAN 2012

DOI: 10.1002/chem.201103051

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 18, Issue 8, pages 2361–2365, February 20, 2012

Additional Information

How to Cite

Ghosh, P. S. and Hamilton, A. D. (2012), Supramolecular Dendrimers: Convenient Synthesis by Programmed Self-Assembly and Tunable Thermoresponsivity. Chem. Eur. J., 18: 2361–2365. doi: 10.1002/chem.201103051

Author Information

  1. 1

    Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107 (USA)

  2. 2

    Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK)

*Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107 (USA)

Publication History

  1. Issue published online: 10 FEB 2012
  2. Article first published online: 20 JAN 2012
  3. Manuscript Received: 15 NOV 2011

Funded by

  • National Science Foundation. Grant Number: CHE0750357

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Keywords:

  • click chemistry;
  • self-assembly;
  • stimuli-responsive;
  • supramolecular dendrimers

Abstract

We report here the noncovalent synthesis of thermosensitive dendrimers. Short oligoguanosine strands were linked to the focal point of a dendron by using “click chemistry”, and quadruplex formation was used to drive the self-assembly process in the presence of metal ions. The dynamic nature of these noncovalent assemblies can be exploited to create combinatorial libraries of dendrimers as demonstrated by the co-assembly of two components. These supramolecular dendrimers showed thermoresponsive behavior that can be tuned by varying the templating cations or the number of guanines in the oligonucleotide strand.

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