The First Well-Defined Silver(I)-Complex-Catalyzed Cycloaddition of Azides onto Terminal Alkynes at Room Temperature

Authors

  • Dr. James McNulty,

    Corresponding author
    1. Department of Chemistry and Chemical-Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4M1 (Canada), Fax: (+1) 905-522-2509
    • Department of Chemistry and Chemical-Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4M1 (Canada), Fax: (+1) 905-522-2509
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  • Kunal Keskar,

    1. Department of Chemistry and Chemical-Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4M1 (Canada), Fax: (+1) 905-522-2509
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  • Dr. Ramesh Vemula

    1. Department of Chemistry and Chemical-Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4M1 (Canada), Fax: (+1) 905-522-2509
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Abstract

original image

Silver(I)-catalyzed click chemistry: Substituted 1,2,3-triazoles are versatile intermediates with an expanding array of applications. The discovery and application of a general AgI-catalyzed azide–alkyne cycloaddition reaction (AAC) leading to 1,2,3-triazoles is reported. The synthesis of a stable, well-defined AgI complex of type [AgI(L2)(OAc)] is described, along with the unprecedented ability of this complex to promote the general Ag-AAC at room temperature (see scheme).

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