A Convenient and Practical Synthesis of Anisoles and Deuterated Anisoles by Palladium-Catalyzed Coupling Reactions of Aryl Bromides and Chlorides

Authors

  • Dr. Saravanan Gowrisankar,

    1. Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock (Germany), Fax: (+49)381-1281-5000
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  • Dr. Helfried Neumann,

    1. Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock (Germany), Fax: (+49)381-1281-5000
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  • Prof. Dr. Matthias Beller

    Corresponding author
    1. Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock (Germany), Fax: (+49)381-1281-5000
    • Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock (Germany), Fax: (+49)381-1281-5000
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Abstract

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Synthesis of anisole: Aryl and heteroaryl halides undergo selective C[BOND]O cross-coupling reactions with methanol in the presence of a Pd(OAc)2/L3 catalyst system. The corresponding ethers were obtained under mild conditions in good yields. The catalytic methodology was also used for the synthesis of labeled deuterated anisoles in good yields (see scheme).

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