Construction of a Graphene Oxide Based Noncovalent Multiple Nanosupramolecular Assembly as a Scaffold for Drug Delivery

Authors

  • Yang Yang,

    1. Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071 (P. R. China), Fax: (+86) 22-2350-3625
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  • Dr. Ying-Ming Zhang,

    1. Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071 (P. R. China), Fax: (+86) 22-2350-3625
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  • Prof. Dr. Yong Chen,

    1. Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071 (P. R. China), Fax: (+86) 22-2350-3625
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  • Di Zhao,

    1. Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071 (P. R. China), Fax: (+86) 22-2350-3625
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  • Jia-Tong Chen,

    1. Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, 300071 (P. R. China)
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  • Prof. Dr. Yu Liu

    Corresponding author
    1. Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071 (P. R. China), Fax: (+86) 22-2350-3625
    • Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071 (P. R. China), Fax: (+86) 22-2350-3625
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Abstract

A multiple supramolecular assembly, in which a folic acid-modified β-cyclodextrin (1) acted as a target unit, an adamantanyl porphyrin (2) acted as a linker unit, and graphene oxide acted as a carrier unit, was successfully fabricated through non-covalent interactions and comprehensively investigated by means of UV/Vis, fluorescence, and X-ray photoelectron spectroscopies, and electron microscopy. Significantly, the graphene oxide unit could associate with the anticancer drug doxorubicin through π–π interactions, and the folic acid-modified β-cyclodextrin unit could recognize the folic acid receptors in cancer cells. Owing to the cooperative contribution of these three units, the resulting multiple supramolecular assembly, after association with doxorubicin, exhibited better drug activity and much lower toxicity than free doxorubicin in vivo.

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