TRAP, a Powerful and Versatile Framework for Gallium-68 Radiopharmaceuticals

Authors

  • Dr. Johannes Notni,

    Corresponding author
    1. Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meissner-Strasse 3, 85748 Garching (Germany)
    2. Klinik für Nuklearmedizin, Technische Universität München, Ismaninger Strasse 22, 81675 München (Germany)
    • Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meissner-Strasse 3, 85748 Garching (Germany)
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  • Jakub Šimeček,

    1. Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meissner-Strasse 3, 85748 Garching (Germany)
    2. Klinik für Nuklearmedizin, Technische Universität München, Ismaninger Strasse 22, 81675 München (Germany)
    3. Department of Inorganic Chemistry, Faculty of Science, Charles University in Prague (Czech Republic)
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  • Prof. Dr. Petr Hermann,

    1. Department of Inorganic Chemistry, Faculty of Science, Charles University in Prague (Czech Republic)
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  • Prof. Dr. Hans-Jürgen Wester

    1. Lehrstuhl für Pharmazeutische Radiochemie, Technische Universität München, Walther-Meissner-Strasse 3, 85748 Garching (Germany)
    2. Klinik für Nuklearmedizin, Technische Universität München, Ismaninger Strasse 22, 81675 München (Germany)
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  • TRAP=Triazacyclononane-phosphinic acid.

Abstract

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A veritable gallium TRAP: Triazacyclononane-phosphinic acid chelators (TRAP) form highly stable complexes with Ga3+ (see figure) extremely efficiently over a wide pH range. Homo- and heteromultimeric bioconjugates can be synthesized in a straightforward manner, all of which renders TRAP a chelator with ideal properties for 68Ga positron emission tomography (PET) imaging agent elaboration.

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