Palladium-Catalyzed Carbonylative Heck Reaction of Aryl Bromides with Vinyl Ethers to 3-Alkoxy Alkenones and Pyrazoles

Authors

  • Johannes Schranck,

    1. Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000
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  • Xiao-Feng Wu,

    1. Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000
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  • Dr. Helfried Neumann,

    1. Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000
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  • Prof. Dr. Matthias Beller

    Corresponding author
    1. Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000
    • Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000
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Abstract

original image

Three COming together: The first carbonylative Heck coupling reaction of aryl bromides and vinyl ethers leading to 1-aryl-3-alkoxy-2-propen-1-ones has been established (see scheme). Based on this coupling methodology, a novel one-pot synthesis of aryl-substituted pyrazoles was also realized.

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