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Versatile Logic Devices Based on Programmable DNA-Regulated Silver-Nanocluster Signal Transducers

Authors

  • Zhenzhen Huang,

    1. Laboratory of Chemical Biology and State Key laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 (PR China), Fax: (+86) 431-85262625
    2. Graduate School of the Chinese Academy of Sciences, Beijing, 100039 (PR China)
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  • Yu Tao,

    1. Laboratory of Chemical Biology and State Key laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 (PR China), Fax: (+86) 431-85262625
    2. Graduate School of the Chinese Academy of Sciences, Beijing, 100039 (PR China)
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  • Dr. Fang Pu,

    1. Laboratory of Chemical Biology and State Key laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 (PR China), Fax: (+86) 431-85262625
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  • Prof. Dr. Jinsong Ren,

    Corresponding author
    1. Laboratory of Chemical Biology and State Key laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 (PR China), Fax: (+86) 431-85262625
    • Laboratory of Chemical Biology and State Key laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 (PR China), Fax: (+86) 431-85262625
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  • Prof. Dr. Xiaogang Qu

    Corresponding author
    1. Laboratory of Chemical Biology and State Key laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 (PR China), Fax: (+86) 431-85262625
    • Laboratory of Chemical Biology and State Key laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 (PR China), Fax: (+86) 431-85262625
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Abstract

A DNA-encoding strategy is reported for the programmable regulation of the fluorescence properties of silver nanoclusters (AgNCs). By taking advantage of the DNA-encoding strategy, aqueous AgNCs were used as signal transducers to convert DNA inputs into fluorescence outputs for the construction of various DNA-based logic gates (AND, OR, INHIBIT, XOR, NOR, XNOR, NAND, and a sequential logic gate). Moreover, a biomolecular keypad that was capable of constructing crossword puzzles was also fabricated. These AgNC-based logic systems showed several advantages, including a simple transducer-introduction strategy, universal design, and biocompatible operation. In addition, this proof of concept opens the door to a new generation of signal transducer materials and provides a general route to versatile biomolecular logic devices for practical applications.

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