Communication

An Efficient Mixed-Ligand Pd Catalytic System to Promote C[BOND]N Coupling for the Synthesis of N-Arylaminotriazole Nucleosides

  1. Yuting Fan1,2,
  2. Dr. Yi Xia2,
  3. Jingjie Tang1,
  4. Dr. Fabio Ziarelli3,
  5. Prof. Fanqi Qu1,
  6. Dr. Palma Rocchi4,
  7. Dr. Juan L. Iovanna4,
  8. Dr. Ling Peng2,*

Article first published online: 20 JAN 2012

DOI: 10.1002/chem.201103918

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 18, Issue 8, pages 2221–2225, February 20, 2012

Additional Information

How to Cite

Fan, Y., Xia, Y., Tang, J., Ziarelli, F., Qu, F., Rocchi, P., Iovanna, J. L. and Peng, L. (2012), An Efficient Mixed-Ligand Pd Catalytic System to Promote C[BOND]N Coupling for the Synthesis of N-Arylaminotriazole Nucleosides. Chem. Eur. J., 18: 2221–2225. doi: 10.1002/chem.201103918

Author Information

  1. 1

    State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, 430072 Wuhan (P.R. China)

  2. 2

    Centre Interdisciplinaire de Nanoscience de Marseille, CNRS UMR 7325, Aix-Marseille Université, 13288 Marseille (France), Fax: (+33) 4-91-82-93-01

  3. 3

    Aix-Marseille Université, Fédération des Sciences Chimiques, Spectropole, 13013 Marseille (France)

  4. 4

    Centre de Recherche en Cancérologie de Marseille, UMR1068 Inserm, Institut Paoli-Calmettes, Aix-Marseille Université, 13288 Marseille (France)

*Centre Interdisciplinaire de Nanoscience de Marseille, CNRS UMR 7325, Aix-Marseille Université, 13288 Marseille (France), Fax: (+33) 4-91-82-93-01

Publication History

  1. Issue published online: 10 FEB 2012
  2. Article first published online: 20 JAN 2012
  3. Manuscript Received: 14 DEC 2011

Funded by

  • National Mega Project on Major Drug Development. Grant Number: 2009ZX09301-014
  • CNRS
  • INSERM
  • China Scholarship Council
  • la Fondation pour la Recherche Médicale

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Keywords:

  • antitumor agents;
  • arylamination;
  • cross-coupling;
  • nucleosides;
  • palladium
Thumbnail image of graphical abstract

Make it unique! A mixed-ligand system of Pd/Synphos/Xantphos promotes effective C[BOND]N coupling in the synthesis of various N-arylaminotriazole and N-arylaminopurine nucleoside analogues. This catalytic system is strikingly powerful and efficient, allowing for unparalleled substrate scope and high product yields as well as promotion of C[BOND]Cl bond activation for C[BOND]N coupling (see scheme).

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