Cover Picture: Rapid and Quantitative Disulfide Bond Formation for a Polypeptide Chain Using a Cyclic Selenoxide Reagent in an Aqueous Medium (Chem. Eur. J. 2/2011)

Authors

  • Kenta Arai,

    1. Department of Chemistry, School of Science, Tokai University, Kitakaname, Hiratsuka-shi, Kanagawa 259-1292 (Japan), Fax: (+81) 463-50-2094
    Search for more papers by this author
  • Dr. Kenichi Dedachi,

    1. Department of Chemistry, School of Science, Tokai University, Kitakaname, Hiratsuka-shi, Kanagawa 259-1292 (Japan), Fax: (+81) 463-50-2094
    Search for more papers by this author
  • Prof. Dr. Michio Iwaoka

    Corresponding author
    1. Department of Chemistry, School of Science, Tokai University, Kitakaname, Hiratsuka-shi, Kanagawa 259-1292 (Japan), Fax: (+81) 463-50-2094
    • Department of Chemistry, School of Science, Tokai University, Kitakaname, Hiratsuka-shi, Kanagawa 259-1292 (Japan), Fax: (+81) 463-50-2094
    Search for more papers by this author

Abstract

original image

An energetic diagram for the stochastic disulfide (SS) bond formation reaction of a polypeptide with a water-soluble selenoxide reagent is depicted on the cover. In their Full Paper on page 481 ff., M. Iwaoka et al. elucidate the reaction mechanism of this SS bond formation, through kinetic analysis and ab initio calculations.

Ancillary