Cover Picture: A Diverted Total Synthesis of Mycolactone Analogues: An Insight into Buruli Ulcer Toxins (Chem. Eur. J. 51/2011)

Authors

  • Anne-Caroline Chany,

    1. Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, Laboratoire de Chimie Organique et Bioorganique EA4566, 3 rue A. Werner, 68093 Mulhouse Cedex (France), Fax: (+33) 389-33-68-60
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  • Dr. Virginie Casarotto,

    1. Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, Laboratoire de Chimie Organique et Bioorganique EA4566, 3 rue A. Werner, 68093 Mulhouse Cedex (France), Fax: (+33) 389-33-68-60
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  • Dr. Marjorie Schmitt,

    1. Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, Laboratoire de Chimie Organique et Bioorganique EA4566, 3 rue A. Werner, 68093 Mulhouse Cedex (France), Fax: (+33) 389-33-68-60
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  • Prof. Dr. Céline Tarnus,

    1. Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, Laboratoire de Chimie Organique et Bioorganique EA4566, 3 rue A. Werner, 68093 Mulhouse Cedex (France), Fax: (+33) 389-33-68-60
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  • Dr. Laure Guenin-Macé,

    1. Institut Pasteur, Immunobiologie de l'Infection, 25 rue du Dr. Roux, 75724 Paris Cedex 15 (France)
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  • Dr. Caroline Demangel,

    1. Institut Pasteur, Immunobiologie de l'Infection, 25 rue du Dr. Roux, 75724 Paris Cedex 15 (France)
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  • Dr. Olivier Mirguet,

    1. Lipid Metabolism DPU, GlaxoSmithkline, 25 av. du Québec, 91951 Les Ulis Cedex (France)
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  • Prof. Dr. Jacques Eustache,

    1. Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, Laboratoire de Chimie Organique et Bioorganique EA4566, 3 rue A. Werner, 68093 Mulhouse Cedex (France), Fax: (+33) 389-33-68-60
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  • Dr. Nicolas Blanchard

    Corresponding author
    1. Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, Laboratoire de Chimie Organique et Bioorganique EA4566, 3 rue A. Werner, 68093 Mulhouse Cedex (France), Fax: (+33) 389-33-68-60
    • Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, Laboratoire de Chimie Organique et Bioorganique EA4566, 3 rue A. Werner, 68093 Mulhouse Cedex (France), Fax: (+33) 389-33-68-60
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Abstract

original image

150 Years after the first description of Buruli ulcer, a devastating mycobacterial infection, a diverted total synthesis (DTS) approach of mycolactone analogues has been developed, relying on metal-mediated and metal-catalyzed transformations. These DTS efforts have provided relevant insights into structure–activity relationships based on cytopathic assays on L929 fibroblasts. The lowest concentration inducing a cytopathic effect was determined for selected analogues, allowing a clear picture to emerge by comparison with the natural toxins. For more details, see the Full Paper by N. Blanchard et al. on page 14413 ff. Cover art by David Vandergucht.

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