150 Years after the first description of Buruli ulcer, a devastating mycobacterial infection, a diverted total synthesis (DTS) approach of mycolactone analogues has been developed, relying on metal-mediated and metal-catalyzed transformations. These DTS efforts have provided relevant insights into structure–activity relationships based on cytopathic assays on L929 fibroblasts. The lowest concentration inducing a cytopathic effect was determined for selected analogues, allowing a clear picture to emerge by comparison with the natural toxins. For more details, see the Full Paper by N. Blanchard et al. on page 14413 ff. Cover art by David Vandergucht.