Inside Cover: Analysis of NAD 2D-NMR Spectra of Saturated Fatty Acids in Polypeptide Aligning Media by Experimental and Modeling Approaches (Chem. Eur. J. 1/2012)

Authors

  • Zeinab Serhan,

    1. RMN en Milieu Orienté, ICMMO, UMR-CNRS 8182, Université de Paris Sud 11, 91405 Orsay Cedex (France)
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  • Andrea Borgogno,

    1. Università di Padova, Dipartimento di Scienze Chimiche, Via Marzolo, 1, 35131 Padova (Italy)
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  • Dr. Isabelle Billault,

    1. RMN en Milieu Orienté, ICMMO, UMR-CNRS 8182, Université de Paris Sud 11, 91405 Orsay Cedex (France)
    2. Université de Nantes, Elucidation of Biosynthesis by Isotopic Spectrometry Group, CEISAM, UMR CNRS 6230, CNRS UMR 6006, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex (France)
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  • Dr. Alberta Ferrarini,

    Corresponding author
    1. Università di Padova, Dipartimento di Scienze Chimiche, Via Marzolo, 1, 35131 Padova (Italy)
    • Università di Padova, Dipartimento di Scienze Chimiche, Via Marzolo, 1, 35131 Padova (Italy)
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  • Dr. Philippe Lesot

    Corresponding author
    1. RMN en Milieu Orienté, ICMMO, UMR-CNRS 8182, Université de Paris Sud 11, 91405 Orsay Cedex (France)
    • RMN en Milieu Orienté, ICMMO, UMR-CNRS 8182, Université de Paris Sud 11, 91405 Orsay Cedex (France)
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Abstract

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Natural abundance deuterium 2D-NMR (NAD 2D-NMR) experiments in oriented solutions of polypeptides have been used to successfully resolve almost all inequivalent deuterium sites of long-chain saturated fatty acid methyl esters, a crucial step for establishing their natural isotopic profile. Theoretical prediction of quadrupolar splittings confirms the spectral assignments and demonstrates the key role of steric solute/polypeptide interactions for the ordering of fatty acid esters. For more details see the Full Paper by P. Lesot, A. Ferrarini et al. on page 117 ff.

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