Emulsion Reactors: A New Technique for the Preparation of Molecular Imaging Probes

Authors

  • Dr. Ryan W. Simms,

    1. Centre for Probe Development and Commercialization, Burke Science Building, Room B231, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1 (Canada), Fax: (+1) 905-522-2509
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  • Dr. Dong Hyun Kim,

    1. Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8 (Canada)
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  • Darren M. Weaver,

    1. Centre for Probe Development and Commercialization, Burke Science Building, Room B231, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1 (Canada), Fax: (+1) 905-522-2509
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  • Dr. Chitra Sundararajan,

    1. Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8 (Canada)
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  • Megan Blacker,

    1. Centre for Probe Development and Commercialization, Burke Science Building, Room B231, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1 (Canada), Fax: (+1) 905-522-2509
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  • Dr. Karin A. Stephenson,

    1. Centre for Probe Development and Commercialization, Burke Science Building, Room B231, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1 (Canada), Fax: (+1) 905-522-2509
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  • Prof. Dr. John F. Valliant

    Corresponding author
    1. Centre for Probe Development and Commercialization, Burke Science Building, Room B231, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1 (Canada), Fax: (+1) 905-522-2509
    2. Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8 (Canada)
    • Centre for Probe Development and Commercialization, Burke Science Building, Room B231, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1 (Canada), Fax: (+1) 905-522-2509
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Abstract

original image

Emulsions for labeling: A new strategy for the preparation of radiolabeled compounds with the use of emulsions was developed. This biocompatible platform demonstrated enhanced yields for labeling biovectors with 99mTc, 18F, and 68Ga. Enhancements included reduction in the amount of starting material required, a decrease in the number of radiochemical impurities, and the ability to perform reactions at room temperature.

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