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Iridium-Catalyzed Enantioselective Hydrogenation of Alkenylboronic Esters

Authors

  • Adnan Ganić,

    1. Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel (Switzerland), Fax: (+41) 61-267-1103
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  • Prof. Dr. Andreas Pfaltz

    Corresponding author
    1. Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel (Switzerland), Fax: (+41) 61-267-1103
    • Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel (Switzerland), Fax: (+41) 61-267-1103
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Abstract

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Choose the right ligand: An iridium complex derived from a phosphino–imidazoline ligand is a highly efficient catalyst for the asymmetric hydrogenation of terminal vinyl boronic esters (see scheme). On the other hand, trisubstituted alkenyl-boronates can be reduced with high activity and good to excellent enantioselectivity employing a pyridine–phosphinite ligand.

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